Top 25 Fittest Mayors in America September 12, Bat Bee Crapaudy toad Emmet ant Serpent. While less gregarious canids generally possess simple repertoires of visual signals, wolves have more varied signals that subtly inter grade in intensity. The two are however mutually intelligible , as North American wolves have been recorded to respond to European-style howls made by biologists. Retrieved September 4, Overall, India supports about , wolves, scattered among several remnant populations.
Men may develop an enlargement of breast tissue, known as gynecomastia, testicular atrophy, and a reduced sperm count. Compounds with a high ratio of androgenic to an anabolic effects are the drug of choice in androgen-replacement therapy e. This disassociation is less marked in humans, where all AAS have significant androgenic effects.
A commonly used protocol for determining the androgenic: The VP weight is an indicator of the androgenic effect, while the LA weight is an indicator of the anabolic effect. Two or more batches of rats are castrated and given no treatment and respectively some AAS of interest. Animal studies also found that fat mass was reduced, but most studies in humans failed to elucidate significant fat mass decrements.
The effects on lean body mass have been shown to be dose-dependent. Both muscle hypertrophy and the formation of new muscle fibers have been observed. The hydration of lean mass remains unaffected by AAS use, although small increments of blood volume cannot be ruled out.
The upper region of the body thorax, neck, shoulders, and upper arm seems to be more susceptible for AAS than other body regions because of predominance of ARs in the upper body. After drug withdrawal, the effects fade away slowly, but may persist for more than 6—12 weeks after cessation of AAS use.
Overall, the exercise where the most significant improvements were observed is the bench press. The measurement of the dissociation between anabolic and androgenic effects among AAS is based largely on a simple although arguably unsophisticated and outdated model involving rat tissue bioassays.
The intracellular metabolism theory explains how and why remarkable dissociation between anabolic and androgenic effects can occur despite the fact that these effects are mediated through the same signaling receptor, and of course why dissociation is invariably incomplete. An animal study found that two different kinds of androgen response elements could differentially respond to testosterone and DHT upon activation of the AR. Changes in endogenous testosterone levels may also contribute to differences in myotrophic—androgenic ratio between testosterone and synthetic AAS.
Testosterone can be metabolized by aromatase into estradiol , and many other AAS can be metabolized into their corresponding estrogenic metabolites as well. The major effect of estrogenicity is gynecomastia woman-like breasts. AAS are androstane or estrane steroids.
As well as others such as 1-dehydrogenation e. The most commonly employed human physiological specimen for detecting AAS usage is urine, although both blood and hair have been investigated for this purpose. The AAS, whether of endogenous or exogenous origin, are subject to extensive hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites may be detectable for up to 30 days after the last use, depending on the specific agent, dose and route of administration.
A number of the drugs have common metabolic pathways, and their excretion profiles may overlap those of the endogenous steroids, making interpretation of testing results a very significant challenge to the analytical chemist. Methods for detection of the substances or their excretion products in urine specimens usually involve gas chromatography—mass spectrometry or liquid chromatography-mass spectrometry. The use of gonadal steroids pre-dates their identification and isolation. Medical use of testicle extract began in the late 19th century while its effects on strength were still being studied.
In the s, it was already known that the testes contain a more powerful androgen than androstenone , and three groups of scientists, funded by competing pharmaceutical companies in the Netherlands, Germany, and Switzerland, raced to isolate it. The chemical synthesis of testosterone was achieved in August that year, when Butenandt and G. Wettstein, announced a patent application in a paper "On the Artificial Preparation of the Testicular Hormone Testosterone Androstenoneol.
Clinical trials on humans, involving either oral doses of methyltestosterone or injections of testosterone propionate , began as early as Kennedy was administered steroids both before and during his presidency. The development of muscle-building properties of testosterone was pursued in the s, in the Soviet Union and in Eastern Bloc countries such as East Germany, where steroid programs were used to enhance the performance of Olympic and other amateur weight lifters.
In response to the success of Russian weightlifters, the U. The new steroid was approved for use in the U. It was most commonly administered to burn victims and the elderly.
The drug's off-label users were mostly bodybuilders and weight lifters. Although Ziegler prescribed only small doses to athletes, he soon discovered that those having abused Dianabol suffered from enlarged prostates and atrophied testes. Three major ideas governed modifications of testosterone into a multitude of AAS: Androgens were discovered in the s and were characterized as having effects described as androgenic i.
Although anabolic steroid was originally intended to specifically describe testosterone-derived steroids with a marked dissociation of anabolic and androgenic effect, it is applied today indiscriminately to all steroids with AR agonism-based anabolic effects regardless of their androgenic potency, including even non-synthetic steroids like testosterone itself.
The legal status of AAS varies from country to country: Unlawful distribution or possession with intent to distribute AAS as a first offense is punished by up to ten years in prison. Those guilty of buying or selling AAS in Canada can be imprisoned for up to 18 months. In Canada, researchers have concluded that steroid use among student athletes is extremely widespread. A study conducted in by the Canadian Centre for Drug-Free Sport found that nearly 83, Canadians between the ages of 11 and 18 use steroids.
AAS are readily available without a prescription in some countries such as Mexico and Thailand. The history of the U. The same act also introduced more stringent controls with higher criminal penalties for offenses involving the illegal distribution of AAS and human growth hormone.
By the early s, after AAS were scheduled in the U. In the Controlled Substances Act, AAS are defined to be any drug or hormonal substance chemically and pharmacologically related to testosterone other than estrogens , progestins , and corticosteroids that promote muscle growth.
The act was amended by the Anabolic Steroid Control Act of , which added prohormones to the list of controlled substances , with effect from January 20, In the United Kingdom, AAS are classified as class C drugs for their illegal abuse potential, which puts them in the same class as benzodiazepines. Part 1 drugs are subject to full import and export controls with possession being an offence without an appropriate prescription. There is no restriction on the possession when it is part of a medicinal product.
Part 2 drugs require a Home Office licence for importation and export unless the substance is in the form of a medicinal product and is for self-administration by a person. Many other countries have similar legislation prohibiting AAS in sports including Denmark,  France,  the Netherlands  and Sweden. United States federal law enforcement officials have expressed concern about AAS use by police officers. It's not that we set out to target cops, but when we're in the middle of an active investigation into steroids, there have been quite a few cases that have led back to police officers," says Lawrence Payne, a spokesman for the United States Drug Enforcement Administration.
Following the murder-suicide of Chris Benoit in , the Oversight and Government Reform Committee investigated steroid usage in the wrestling industry. The documents stated that 75 wrestlers—roughly 40 percent—had tested positive for drug use since , most commonly for steroids. AAS are frequently produced in pharmaceutical laboratories, but, in nations where stricter laws are present, they are also produced in small home-made underground laboratories, usually from raw substances imported from abroad.
As with most significant smuggling operations, organized crime is involved. In the late s, the worldwide trade in illicit AAS increased significantly, and authorities announced record captures on three continents. In , Finnish authorities announced a record seizure of A year later, the DEA seized In the first three months of , Australian customs reported a record seizures of AAS shipments.
Illegal AAS are sometimes sold at gyms and competitions, and through the mail, but may also be obtained through pharmacists, veterinarians, and physicians. AAS, alone and in combination with progestogens , have been studied as potential male hormonal contraceptives. From Wikipedia, the free encyclopedia.
This article is about androgens as medications. For androgens as natural hormones, see Androgen. Ergogenic use of anabolic steroids. Use of performance-enhancing drugs in sport.
Illegal trade in anabolic steroids. Pharmacy and Pharmacology portal. British Journal of Pharmacology. Houglum J, Harrelson GL, eds. Principles of Pharmacology for Athletic Trainers 2nd ed. Int J Sports Med. Mini Rev Med Chem. Anabolic-androgenic steroid therapy in the treatment of chronic diseases". Clinics in Endocrinology and Metabolism. Pharmacology Application in Athletic Training. Clinical Guidelines for Prevention and Treatment.
Royal College of Physicians. Anabolic Steroids and the Athlete, 2d ed. Food and Drug Administration. Retrieved 21 June A systematic review and meta-analysis". Expert Opinion on Pharmacotherapy. Current Allergy and Asthma Reports. Clinics in Liver Disease. The named reference Llewellyn was invoked but never defined see the help page. Neidle 19 March Pharmacology and Therapeutics for Dentistry - E-Book. The gray wolf was exterminated in Denmark in and Norway's last wolf was killed in The species was decimated in 20th century Finland, despite regular dispersals from Russia.
The gray wolf was only present in the eastern and northern parts of Finland by , though its numbers increased after World War II. In Central Europe , wolves were dramatically reduced in number during the early nineteenth century, because of organized hunts and reductions in ungulate populations. In Bavaria , the last wolf was killed in , and had disappeared from the Rhine regions by Today, wolves have returned to the area. The louveterie was abolished after the French Revolution in , but was re-established in In , up to 1, wolves were killed, with many more by poison.
In Eastern Europe , wolves were never fully exterminated, because of the area's contiguity with Asia and its large forested areas. However, Eastern European wolf populations were reduced to very low numbers by the late nineteenth century. Wolves were extirpated in Slovakia during the first decade of the twentieth century and, by the mid-twentieth century, could only be found in a few forested areas in eastern Poland. Wolves in the eastern Balkans benefitted from the region's contiguity with the former Soviet Union and large areas of plains, mountains and farmlands.
Wolves in Hungary occurred in only half the country around the start of the 20th century, and were largely restricted to the Carpathian Basin.
Wolf populations in Romania remained largely substantial, with an average of 2, wolves being killed annually out of a population of 4, from — An all-time low was reached in , when the population was reduced to 1, animals. The extermination of wolves in Bulgaria was relatively recent, as a previous population of about 1, animals in was reduced to about — in In Greece, the species disappeared from the southern Peloponnese in Despite periods of intense hunting during the eighteenth century, wolves never disappeared in the western Balkans, from Albania to the former Yugoslavia.
In Southern Europe , wolf extermination was not as complete as in Northern Europe, because of greater cultural tolerance of the species. Wolf populations only began declining in the Iberian Peninsula in the early 19th-century, and was reduced by a half of its original size by Wolf bounties were regularly paid in Italy as late as The recovery of European wolf populations began after the s, when traditional pastoral and rural economies declined and thus removed the need to heavily persecute wolves.
By the s, small and isolated wolf populations expanded in the wake of decreased human density in rural areas and the recovery of wild prey populations. The gray wolf has been fully protected in Italy since , and now holds a population of over 1,, By the wolves in the Western Alps imposed a significant burden on traditional sheep and goat husbandry with a loss of over 5, animals in In Spain , the species occurs in Galicia , Leon , and Asturias.
Although hundreds of Iberian wolves are illegally killed annually, the population has expanded south across the river Duero and east to the Asturias and Pyrenees Mountains. In , wolves began recolonising central Sweden after a twelve-year absence, and have since expanded into southern Norway.
As of , the total number of Swedish and Norwegian wolves is estimated to be at least one hundred, including eleven breeding pairs. The gray wolf is fully protected in Sweden and partially controlled in Norway. The Scandinavian wolf populations owe their continued existence to neighbouring Finland's contiguity with the Republic of Karelia , which houses a large population of wolves. Furthermore, the decline in the moose populations has reduced the wolf's food supply. Wolf populations in Poland have increased to about — individuals since being classified as a game species in Poland plays a fundamental role in providing routes of expansion into neighbouring Central European countries.
In the east, its range overlaps with populations in Lithuania, Belarus , Ukraine , and Slovakia. A population in western Poland expanded into eastern Germany and in the first pups were born on German territory. A few Slovakian wolves disperse into the Czech Republic, where they are afforded full protection. Wolves in Slovakia, Ukraine and Croatia may disperse into Hungary, where the lack of cover hinders the buildup of an autonomous population. Although wolves have special status in Hungary, they may be hunted with a year-round permit if they cause problems.
Romania has a large population of wolves, numbering 2, animals. The wolf has been a protected animal in Romania since , although the law is not enforced. The number of wolves in Albania and Macedonia is largely unknown, despite the importance the two countries have in linking wolf populations from Greece to those of Bosnia and Herzegovina and Croatia. Although protected, sometimes wolves are still illegally killed in Greece, and their future is uncertain.
Wolf numbers have declined in Bosnia and Herzegovina since , while the species is fully protected in neighbouring Croatia and Slovenia. During the 19th century, gray wolves were widespread in many parts of the Holy Land east and west of the Jordan River.
However, they decreased considerably in number between and , largely because of persecution by farmers. Soviet wolf populations reached a low around , disappearing over much of European Russia. The population increased again by to about 75,, with 32, being killed in By the s, wolf extermination remained a priority in the NWP and Awadh.
Overall, over , wolves were killed for bounties in British India between and The wolf was deemed a threat to ranching, which the Meiji government promoted at the time, and targeted via a bounty system and a direct chemical extermination campaign inspired by the similar contemporary American campaign. The last Japanese wolf was a male killed on January 23, near Washikaguchi now called Higashi Yoshiro.
Japanese wolves likely underwent a process of island dwarfism 7,—13, years ago in response to these climatological and ecological pressures. There is little reliable data on the status of wolves in the Middle East , save for those in Israel and Saudi Arabia , though their numbers appear to be stable, and are likely to remain so. Israel's conservation policies and effective law enforcement maintain a moderately sized wolf population, which radiates into neighbouring countries, while Saudi Arabia has vast tracts of desert, where about — wolves live undisturbed.
The mountains of Turkey have served as a refuge for the few wolves remaining in Syria. A small wolf population occurs in the Golan Heights , and is well protected by the military activities there. Wolves living in the southern Negev desert are contiguous with populations living in the Egyptian Sinai and Jordan.
Throughout the Middle East, the species is only protected in Israel. Elsewhere, it can be hunted year-round by Bedouins. Little is known of current wolf populations in Iran, which once occurred throughout the country in low densities during the mids. The northern regions of Afghanistan and Pakistan are important strongholds for the wolf. Overall, India supports about , wolves, scattered among several remnant populations.
Although protected since , Indian wolves are classed as endangered, with many populations lingering in low numbers or living in areas increasingly used by humans.
Although present in Nepal and Bhutan , there is no information of wolves occurring there. Wolf populations throughout Northern and Central Asia are largely unknown, but are estimated in the hundreds of thousands based on annual harvests.
Since the fall of the Soviet Union , continent-wide extermination of wolves has ceased, and wolf populations have increased to about 25,—30, animals throughout the former Soviet Union. In China and Mongolia , wolves are only protected in reserves. Mongolian populations have been estimated at 10,—30,, while the status of wolves in China is more fragmentary. The north has a declining population of an estimated wolves, while Xinjiang and Tibet hold about 10, and 2, respectively.
It exists in southern China, which refutes claims made by some researchers in the Western world that the wolf had never existed in southern China. It occurred all over the mainland, save for the southeastern United States, California west of the Sierra Nevada , and the tropical and subtropical areas of Mexico.
Large continental islands occupied by wolves included Newfoundland , Vancouver Island , southeastern Alaskan islands, and throughout the Arctic Archipelago and Greenland. In his November 6, letter to the French Minister of the Marine, Louis Denys de La Ronde reported that the island was home to wolves "of a prodigious size", and sent a wolf pelt back to France to substantiate his claim.
As the island was cleared for settlement, the gray wolf population may have been extirpated, or relocated to the mainland across the winter ice: The decline of North American wolf populations coincided with increasing human populations and the expansion of agriculture. By the start of the 20th century, the species had almost disappeared from the eastern USA, excepting some areas of the Appalachians and the northwestern Great Lakes Region.
In Canada, the gray wolf was extirpated in New Brunswick and Nova Scotia between and , and in Newfoundland around It vanished from the southern regions of Quebec and Ontario between and The gray wolf's decline in the prairies began with the extermination of the American bison and other ungulates in the s—70s. From —, the gray wolf was virtually eliminated from the western USA and adjoining parts of Canada, because of intensive predator control programs aimed at eradicating the species.
The gray wolf was exterminated by federal and state governments from all of the USA by , except in Alaska and northern Minnesota. The decline in North American wolf populations was reversed from the s to the early s, particularly in southwestern Canada, because of expanding ungulate populations resulting from improved regulation of big game hunting.
This increase triggered a resumption of wolf control in western and northern Canada. Thousands of wolves were killed from the early s to the early s, mostly by poisoning. This campaign was halted and wolf populations increased again by the mids. The species' modern range in North America is mostly confined to Alaska and Canada, with populations also occurring in northern Minnesota, northern Wisconsin and Michigan 's Upper Peninsula , and small portions of Washington , Idaho , northern Oregon , and Montana.
A functional wolf population should exist in California by according to estimates by state wildlife officials. In addition, the Mexican wolf Canis lupus baileyi was reintroduced to Arizona and New Mexico in Canada is home to about 52,—60, wolves, whose legal status varies according to province and territory. First Nations residents may hunt wolves without restriction, and some provinces require licenses for residents to hunt wolves while others do not.
In Alberta , wolves on private land may be baited and hunted by the landowner without requiring a license, and in some areas, wolf hunting bounty programs exist. In Alaska, the gray wolf population is estimated at 6,—7,, and can be legally harvested during hunting and trapping seasons, with bag limits and other restrictions.
As of , there are wolves in 28 packs in Yellowstone, and wolves in 25 packs in Idaho. Reintroduced Mexican wolves in Arizona and New Mexico are protected under the ESA and, as of late , number 28 individuals in eight packs.
Viral diseases carried by wolves include rabies , canine distemper , canine parvovirus , infectious canine hepatitis , papillomatosis , and canine coronavirus. Infected wolves do not show any fear of humans, with most documented wolf attacks on people being attributed to rabid animals.
Although canine distemper is lethal in dogs, it has not been recorded to kill wolves, except in Canada and Alaska. The canine parvovirus, which causes death by dehydration , electrolyte imbalance , and endotoxic shock or sepsis , is largely survivable in wolves, but can be lethal to pups. Wolves may catch infectious canine hepatitis from dogs, though there are no records of wolves dying from it. Papillomatosis has been recorded only once in wolves, and likely doesn't cause serious illness or death, though it may alter feeding behaviors.
The canine coronavirus has been recorded in Alaskan wolves, with infections being most prevalent in winter months. Bacterial diseases carried by wolves include brucellosis , lyme disease , leptospirosis , tularemia , bovine tuberculosis ,  listeriosis , anthrax and foot and mouth disease.
While adult wolves tend not to show any clinical signs, it can severely weaken the pups of infected females. Although lyme disease can debilitate individual wolves, it does not appear to have any significant effect on wolf populations. Leptospirosis can be contracted through contact with infected prey or urine, and can cause fever , anorexia , vomiting, anemia , hematuria , icterus , and death.
Wolves living near farms are more vulnerable to the disease than those living in the wilderness, probably because of prolonged contact with infected domestic animal waste. Wolves may catch tularemia from lagomorph prey, though its effect on wolves is unknown. Although bovine tuberculosis is not considered a major threat to wolves, it has been recorded to have once killed two wolf pups in Canada.
Wolves carry ectoparasites and endoparasites , with wolves in the former Soviet Union having been recorded to carry at least 50 species. In areas where wolves inhabit pastoral areas, the parasites can be spread to livestock. Wolves are often infested with a variety of arthropod exoparasites, including fleas , ticks , lice , and mites. The most harmful to wolves, particularly pups, is Sarcoptes scabiei or mange mite ,  though they rarely develop full blown mange , unlike foxes.
Ticks of the genus Ixodes can infect wolves with Lyme disease and Rocky Mountain spotted fever. Other ectoparasites include biting lice, sucking lice and the fleas Pulex irritans and Ctenocephalides canis.
Endoparasites known to infect wolves include protozoans and helminths flukes , tapeworms , roundworms and thorny-headed worms. Of 30, protozoan species, only a few have been recorded to infect wolves: Isospora , Toxoplasma , Sarcocystis , Babesia , and Giardia. Upon reaching maturity, Alaria migrates to the wolf's intestine, but harms it little. Metorchis conjunctus , which enters wolves through eating fish, infects the wolf's liver or gall bladder, causing liver disease , inflammation of the pancreas, and emaciation.
Most other fluke species reside in the wolf's intestine, though Paragonimus westermani lives in the lungs. Tapeworms are commonly found in wolves, as their primary hosts are ungulates, small mammals, and fish, which wolves feed upon.
Tapeworms generally cause little harm in wolves, though this depends on the number and size of the parasites, and the sensitivity of the host. Symptoms often include constipation , toxic and allergic reactions , irritation of the intestinal mucosa , and malnutrition.
Infections by the tapeworm Echinococcus granulosus in ungulate populations tend to increase in areas with high wolf densities, as wolves can shed Echinoccocus eggs in their feces onto grazing areas. Wolves can carry over 30 roundworm species, though most roundworm infections appear benign, depending on the number of worms and the age of the host. Ancylostoma caninum attaches itself on the intestinal wall to feed on the host's blood, and can cause hyperchromic anemia , emaciation, diarrhea , and possibly death.
Toxocara canis , a hookworm known to infect wolf pups in utero, can cause intestinal irritation, bloating, vomiting, and diarrhea. Wolves can tolerate low levels of Dirofilaria immitis for many years without showing any ill effects, though high levels can kill wolves through cardiac enlargement and congestive hepatopathy. Wolves probably become infected with Trichinella spiralis by eating infected ungulates. Nicolla skrjabini , Macrocantorhynchus catulinus , and Moniliformis moniliformis.
Human presence appears to stress wolves, as seen by increased cortisol levels in instances such as snowmobiling near their territory. Old English literature contains several instances of Anglo-Saxon kings and warriors taking on wulf as a prefix or suffix in their names.
Wolf-related names were also common among pre-Christian Germanic warriors: Ancient Greek literature is similar: Autolycus "the wolf itself" , Lycurgus "wolf-work".
The Latin for "female prostitute" is lupa , and the most famous brothel in Pompeii was the Lupanar. The wolf is a common motif in the foundational mythologies and cosmologies of peoples throughout Eurasia and North America corresponding to the historical extent of the habitat of the gray wolf. The obvious attribute of the wolf is its nature of a predator , and correspondingly it is strongly associated with danger and destruction, making it the symbol of the warrior on one hand, and that of the devil on the other.
The modern trope of the Big Bad Wolf is a development of this. The wolf holds great importance in the cultures and religions of the nomadic peoples, both of the Eurasian steppe and of the North American Plains. In many cultures, the identification of the warrior with the wolf totemism gave rise to the notion of Lycanthropy , the mythical or ritual identification of man and wolf. Aesop featured wolves in several of his fables , playing on the concerns of Ancient Greece 's settled, sheep-herding world.
His most famous is the fable of The Boy Who Cried Wolf , which is directed at those who knowingly raise false alarms, and from which the idiomatic phrase " to cry wolf " is derived. Some of his other fables concentrate on maintaining the trust between shepherds and guard dogs in their vigilance against wolves, as well as anxieties over the close relationship between wolves and dogs.
Although Aesop used wolves to warn, criticize and moralize about human behavior, his portrayals added to the wolf's image as a deceitful and dangerous animal. Although portrayed as loyal, honest and moral, Isengrim is forever the victim of Reynard's wit and cruelty, often dying at the end of each story. The tale of Little Red Riding Hood , first written in by Charles Perrault , is largely considered to have had more influence than any other source of literature in forging the wolf's negative reputation in the western world.
The wolf in this story is portrayed as a potential rapist , capable of imitating human speech. Tolstoy's War and Peace and Chekhov's Peasants both feature scenes in which wolves are hunted with hounds and borzois. Although credited with having changed popular perceptions on wolves by portraying them as loving, cooperative and noble, it has been criticized for its idealization of wolves and its factual inaccuracies.
The wolf is a frequent charge in English armory. It is illustrated as a supporter on the shields of Lord Welby , Rendel , and Viscount Wolseley , and can be found on the coat of arms of Lovett and the vast majority of the Wilsons and Lows.
The demi-wolf is a common crest , appearing in the arms and crests of members of many families, including that of the Wolfes , whose crest depicts a demi-wolf holding a crown in its paws, in reference to the assistance the family gave to Charles II during the battle of Worcester. Wolf heads are common in Scottish heraldry , particularly in the coats of Clan Robertson and Skene.
The wolf is the most common animal in Spanish heraldry , and is often depicted as carrying a lamb in its mouth, or across its back. It is the unofficial symbol of the spetsnaz , and serves as the logo of the Turkish Grey Wolves.
Livestock depredation has been one of the primary reasons for hunting wolves, and can pose a severe problem for wolf conservation: Being the most abundant carnivores, feral and free-ranging dogs have the greatest potential to compete with wolves. A review of the studies in the competitive effects of dogs on sympatric carnivores did not mention any research on competition between dogs and wolves.
Wolves kill dogs on occasion, with some wolf populations relying on dogs as an important food source. Wolves may display unusually bold behavior when attacking dogs accompanied by people, sometimes ignoring nearby humans. Large hunting dogs such as Swedish elkhounds are more likely to survive wolf attacks because of their better ability to defend themselves.
Although the numbers of dogs killed each year are relatively low, it induces a fear of wolves entering villages and farmyards to take dogs. In many cultures, there are strong social and emotional bonds between humans and their dogs that can be seen as family members or working team members.
The loss of a dog can lead to strong emotional responses with demands for more liberal wolf hunting regulations. Dogs that are employed to guard sheep help to mitigate human—wolf conflicts, and are often proposed as one of the non-lethal tools in the conservation of wolves.
The fear of wolves has been pervasive in many societies, though humans are not part of the wolf's natural prey. Predatory attacks attacks by wolves treating humans as food may be preceded by a long period of habituation , in which wolves gradually lose their fear of humans.
The victims are repeatedly bitten on the head and face, and are then dragged off and consumed, unless the wolves are driven off. Such attacks typically occur only locally, and do not stop until the wolves involved are eliminated.
Predatory attacks can occur at any time of the year, with a peak in the June—August period, when the chances of people entering forested areas for livestock grazing or berry and mushroom picking increase,  though cases of non-rabid wolf attacks in winter have been recorded in Belarus , Kirov and Irkutsk oblasts, Karelia and Ukraine.
The majority of victims of predatory wolf attacks are children under the age of 18 and, in the rare cases where adults are killed, the victims are almost always women. Cases of rabid wolves are low when compared to other species, as wolves do not serve as primary reservoirs of the disease, but can be infected by animals such as dogs, jackals and foxes.
Incidents of rabies in wolves are very rare in North America, though numerous in the eastern Mediterranean , Middle East and Central Asia.
Wolves apparently develop the "furious" phase of rabies to a very high degree which, coupled with their size and strength, makes rabid wolves perhaps the most dangerous of rabid animals,  with bites from rabid wolves being 15 times more dangerous than those of rabid dogs. Most rabid wolf attacks occur in the spring and autumn periods.
Unlike with predatory attacks, the victims of rabid wolves are not eaten, and the attacks generally only occur on a single day. The victims are chosen at random, though the majority of cases involve adult men.
In the half-century up to , there were eight fatal attacks in Europe and Russia, and more than in south Asia. Wolves are difficult to hunt because of their elusiveness, sharp senses, high endurance, and ability to quickly incapacitate and kill hunting dogs.
This method relies heavily on the wolf's fear of human scents, though it can lose its effectiveness when wolves become accustomed to the smell. Wild wolves are sometimes kept as exotic pets and, in some rarer occasions, as working animals. Although closely related to domesticated dogs , wolves do not show the same tractability as dogs in living alongside humans, and generally, much more work is required in order to obtain the same amount of reliability.
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